A synthetic analog of PGF2β.

Molecular Formula: C₅₇H₉₂O₆ Formula Weight: 873.4

An analog of AEA that potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons; selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis; inhibits the transport of AEA with an IC₅₀ value of 1 µM in rat…

A potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3 (IC₅₀ values are 0.06-0.4, 1-12, and 1-13 nM, respectively); ineffective against SK4 at 1 µM.

This bottle contains filtered HEPES (1 M), pH 7.5. The buffering range for HEPES is pH 6.8-8.2 and can be adjusted with KOH or NaOH. It is ready to use as supplied.

A derivative of halopemide which potently inhibits both PLD1 (IC₅₀ = 25 nM) and PLD2 (IC₅₀ = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.

A class III antiarrhythmic agent; inhibits KCNH2 with an IC₅₀ value of 1 µM; also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

A potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM); produced in vivo via the metabolism of the prodrug acetorphan.

A thiol-reactive probe that can be used to label proteins at cysteine residues.

The major metabolite of the gastric proton pump inhibitor, omeprazole; produced by CYP3A4 sulfoxidation of esomeprazole.

A neutral RARα-selective antagonist (Ki = 2.5 nM); antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.

A natural phytochemical with anti-inflammatory effects; inhibits the growth of leukemia cells (IC₅₀ = 1.5 μg/ml), inducing apoptosis; at 15 μM, suppresses STAT3-regulated gene expression and prevents angiogenesis.

A-77-01 is a potent inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-β on lung epithelial Mv1Lu cells. It completely blocks…

A symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response (IC₅₀ = 5 nM in a cell-reporter assay); passes through the blood-brain barrier and significantly enhances learning and memory in mice and rats.

15(R)-HEDE is isolated by the chromatographic resolution of (±)15-HEDE. There are no reports of biological activity associated with 15(R)-HEDE in the literature.

An isotopically enriched form of a PUFA with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.

A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC₅₀ values of 67 and 289 nM for the human and rat isoforms, respectively; attenuates cold allodynia following nerve injury and suppresses neuronal activity in response to mechanical stimulation.

A selective, ATP-competitive inhibitor of Cdk9, 2, and 7 with IC₅₀ values of 4, 38, and 62 nM, respectively; blocks the cell cycle, inhibits transcription, and induces apoptosis in multiple myeloma RPMI-8226 cells with an IC₉₀ value of 0.3 µM.

An analog of scriptaid that lacks scriptaid’s HDAC inhibitory effects; used as a negative control in experiments involving scriptaid.

A selective non-peptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC₅₀ = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor; effectively activates µ/δ receptor heteromers (EC₅₀ = 52.8 nM) but not κ/δ or μ/κ heteromers.

A classical inhibitor of complex I of the mitochondrial electron transport chain, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC₅₀ values of 28.8 and 5.1 nM, respectively; used in animal models of Parkinson’s disease.

A quinone derivative that inhibits red blood cell PLA2 with a Ki value of 130 µM.

A potent inhibitor of tubulin polymerization with strong inhibitory activity on tumor cell growth.

A selective, potent, and cell-permeable inhibitor of mTOR (IC₅₀ = 4.3 nM) which blocks signaling through both mTORC1 and mTORC2; induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines and reduces tumor growth in nude mice with PTEN-null tumors.

2-O-ethyl PAF C-16 is a synthetic PAF analog which contains an ethyl group, attached by an ether linkage, at the sn-2 position. It is a less potent agonist than methylcarbamyl PAF C-16 in the induction of platelet aggregation in both human and rabbit PRP. 2-O-ethyl PAF C-16 causes aggregation of…

A phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions.

A potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd value of 43 nM.

A potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions; relaxes rat aorta rings (ED₅₀ = 19.3 μM) and has been used as a vasodilator in the treatment of hypertensio

A time-dependent, non-specific COX inhibitor with IC₅₀ values of 1.5 and 9.7 µM for human recombinant COX-1 and COX-2, respectively.

A dihydroxybenzoic acid phenolic compound that demonstrates free radical scavenging capability (IC₅₀ = 16.3 μM) in a DPPH radical scavenging activity assay; possesses anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities.

A selective inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to AA; orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.

Lyso-PC is the ubiquitous lipid species generated following PLA2 hydrolysis of phosphatidylcholine. The hydrolysis of phospholipids by arachidonyl-selective PLA2s is the initiating event in many eicosanoid-based signal transduction pathways. Many other reactions also generate phosphatidylcholine…