NEW! Life Science, 5 mg
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Olivetolic Acid
Cayman ChemicalAn analytical reference standard categorized as an intermediate in the phytocannabinoid biosynthetic pathway; a precursor in the synthesis of CBGA, ?9-THC, and CBD; intended for research and forensic applications
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Fialuridine
Cayman ChemicalA nucleoside analog with antiviral activity, inhibiting thymidine kinases from herpes simplex virus types 1 and 2 with Ki values of 0.14 and 0.95 µM, while blocking green monkey Vero cell thymidine kinase less effectively (Ki = 53 µM).
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CPI-203
Cayman ChemicalA primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p. administration; inhibits BRD4 binding and action in vitro or in cells; arrests the growth of leukemia T cells in vitro (EC50 = 91 nM) and rapidly suppresses leukemia burden in mice.
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17a,20ß-Dihydroxy-4-pregnen-3-one
Cayman ChemicalAn endogenous, maturation-inducing steroid that at 1 µg/ml induces germinal vesicle breakdown in oocytes from several teleost species; can also influence spermiation by stimulating milt production when administered at 5 mg/kg to various male teleosts.
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Bromosporine
LKT LabsBromosporine is an inhibitor of BET bromodomains (BRDs) BRD2, BRD4, BRD9, and CECR2; it may exhibit anticancer potential.
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Sphingosine-1-Phosphate
Cayman ChemicalA potent lipid signaling molecule that exhibits a wide range of biological activities; it enhances cell growth and inhibits the normal apoptotic response to a variety of stimuli.
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Regadenoson
Cayman ChemicalA selective, short-acting adenosine A2A receptor agonist (Ki = 1.1 nM for pig striatum A2A receptor); used to induce hyperemia, particularly in the context of myocardial perfusion imaging.
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Licofelone
Cayman ChemicalA dual inhibitor of COX and LOX pathways, that decreases levels of PGE2, LTB4, and lipoxins and prevents LPS-stimulated IL-1β expression.
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Unoprostone isopropyl ester
Cayman ChemicalUnoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of PGF2α. Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate…
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Cannabidiol
Cayman ChemicalAn analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications
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Echinomycin
Cayman ChemicalA cell-permeable inhibitor of HIF-1-mediated gene transcription which acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the HRE; reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50…
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NQDI-1
Cayman ChemicalA selective inhibitor of ASK1 (IC50 = 3 μM; Ki = 500 nM); promotes survival of induced pluripotent stem cell populations and protects neurons from reactive oxygen species-induced apoptosis in a model of ischemia.
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NBQX (sodium salt)
Cayman ChemicalA water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively); does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM).
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Fulvestrant
Cayman ChemicalA potent ER antagonist that works by both down-regulating and degrading ERα; efficacious in the treatment of estrogen-sensitive breast cancer; fully activates ER on hippocampal neurons.
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CAY10625
Cayman ChemicalAn antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO with an IC50 value of 2.2 µM; sensitizes cells to apoptotic stimuli.
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Lutein
Cayman ChemicalA natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina; a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.
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(S)-MG132
Cayman ChemicalA potent, reversible, and cell permeable proteasome inhibitor; inhibits cell growth in B16 and IPC227F cells with IC50 values of 42 and 77 nM, respectively; inhibits NF-κB activation, sensitizing a variety of carcinoma cell lines to apoptosis.
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Doxorubicin (hydrochloride)
Cayman ChemicalAn anthracycline antitumor antibiotic agent that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks; inhibits nucleic acid synthesis and induces apoptosis by intercalating within DNA.
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CID-1067700
Cayman ChemicalA competitive inhibitor of nucleotide binding by Ras-related GTPases; binds Rab7 (Ki = 13 nM), preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21 nM, respectively.
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Ginsenoside Rg3
Cayman ChemicalA panaxadiol that has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions; induces apoptosis and inhibits angiogenesis in a variety of cancer models.
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UNC1999
Cayman ChemicalA selective, cell-permeable EZH2 inhibitor (IC50 = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC50 value of 124 nM.
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Carfilzomib
Cayman ChemicalAn irreversible inhibitor of the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases; induces cell cycle arrest and…
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Cannabigerovarin
Cayman ChemicalAn analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications
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(-)-6a-hydroxy Cannabidiol
Cayman ChemicalAn analytical reference standard categorized as a phytocannabinoid metabolite; a cannabidiol metabolite; intended for research and forensic applications
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CBGB
Cayman ChemicalAn analytical reference standard that is structurally similar to known phytocannabinoids; intended for research and forensic applications
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CX-6258
Cayman ChemicalA potent, reversible, orally bioavailable inhibitor of Pim-1, -2, and -3 (IC50s = 5, 25, and 16 nM, respectively); dose-dependently blocks the phosphorylation of the Pim targets Bad, 4E-BP1, and NKX3.1; acts synergistically with chemotherapeutic drugs.
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ß-Nicotyrine
Cayman ChemicalAn alkaloid metabolite of nicotine as well as a major product of its pyrolysis; binds comparably to CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), but appears to more effectively inactivate CYP2A6.
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Taurocholic Acid 3-sulfate
Cayman ChemicalA sulfated form of taurocholic acid that may be involved in the elimination and detoxification of bile acids during hepatobiliary diseases.
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GSK-3ß Inhibitor II
Cayman ChemicalGSK3β Inhibitor II is a potent inhibitor of glycogen synthase kinase-3β (GSK3β; IC50 = 390 nM) that does not inhibit GSK-3α. Also referred to as tip-oxadiazole, this compound blocks the functional regulation of p53 by GSK3β, decreasing levels of MDM2, p21, and…
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SB-431542
Cayman ChemicalA potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM), ALK4 (IC50 = 140 nM) and, less effectively, ALK7; suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.