NEW! Life Science, 5 g
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2-phenyl-3-methyl-Quinoxaline
Cayman ChemicalA synthetic intermediate useful for pharmaceutical synthesis.
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6-Thioguanine
Cayman ChemicalA thio analog of the purine base guanine that incorporates into DNA during replication, inducing double-strand breaks that destabilize its structure and result in cytotoxicity; used as a chemotherapeutic for acute leukemia and other types of cancer, including BRCA2-mutated tumors.
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Amphotericin B
Cayman ChemicalA polyene macrolide used in the treatment of infections caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures; binds with ergosterol in fungal cell membranes, altering membrane permeability and ultimately…
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Griseofulvin
Cayman ChemicalA natural bacterial product used, in certain formulations, as an oral antibiotic for fungal infections of the skin; alters microtubule dynamics, resulting in metaphase arrest.
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Nicardipine (hydrochloride)
Cayman ChemicalA dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity; selectively inhibits adenosine A3 receptors (Ki = 3.25 µM) and CYP3A4 catalytic activity (IC50 = 0.148 µM); activates TRPA1 channels, producing an increase in Ca2+…
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L-Glutathione, reduced
Cayman ChemicalGSH is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of…
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2'-Deoxyadenosine-5'-monophosphate
Cayman ChemicalA derivative of AMP that has been used in the synthesis of novel photoaffinity labels for incorporation into DNA and to study adenosine-based interactions during DNA synthesis and DNA damage.
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5-Fluorocytosine
Cayman ChemicalAn antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil, a cytotoxic drug that inhibits viral infections and has cytotoxic effects on cancer cells.
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Taurodeoxycholic Acid (sodium salt)
Cayman ChemicalA bile salt formed in the liver by conjugation of deoxycholate with taurine; used to solubilize lipids and membrane-bound proteins and also as a vehicle to assist with vaccine delivery.
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Xylazine
Cayman ChemicalAn agonist of α2 adrenergic receptors (Ki = 194 nM); used for sedation, anesthesia, and analgesia in non-human mammals.
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2-Hydroxypropyl-ß-cyclodextrin
Cayman ChemicalA cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.
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Oleic Acid
Cayman ChemicalOleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet…
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Probucol
Cayman ChemicalA potent antioxidant that inhibits the oxidation of cholesterol in LDL and HDL by impairing the translocation of ABCA1 from intracellular compartments to the plasma membrane.
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L-(-)-Fucose
Cayman ChemicalA deoxyhexose monosaccharide found on N- and O-linked glycans and glycolipids that exists either as a terminal modification of glycan structures or serves as a point of attachment for adding other sugars; plays a role in A and B blood group antigen substructure determination, selectin-mediated…
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Ciclopirox Olamine
LKT LabsCiclopirox is a hydroxypyridone compound that exhibits antifungal, anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. This compound acts as a metal ion chelator, preventing peroxide degradation. Ciclopirox modulates generation of ROS in a PKA/Ras1/Ras2-dependent manner,…
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(+)-Catechin (hydrate)
Cayman ChemicalCatechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid…
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Amiodarone (hydrochloride)
Cayman ChemicalA class III antiarrhythmic agent; inhibits KCNH2 with an IC50 value of 1 µM; also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.
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Trimethoprim
Cayman ChemicalA synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively); commonly used in combination with sulfamethoxazole to minimize acquired resistance.
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Quetiapine (hemifumarate)
Cayman ChemicalAn atypical, second generation antipsychotic compound that has effects at multiple receptors; antagonizes dopamine D1, D2, and D3 receptors, serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors, and α1A, α1B, and α2C adrenergic receptors.
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4-Methylumbelliferyl-ß-D-Glucuronide (hydrate)
Cayman ChemicalA fluorogenic substrate of β-glucuronidase that upon cleavage yields a blue fluorescent end product that can be monitored by UV light; typically used in the GUS reporter system for fluorescent detection of β-glucuronidase gene expression in E. coli and transformed plants.
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Ketoconazole
Cayman ChemicalAn orally active broad spectrum antifungal agent that blocks ergosterol biosynthesis by inhibiting the fungal CYP isoform CYP51; potently inhibits the mammalian analog CYP51A1 (IC50 = 63.5 nM), as well as a variety of other CYP isoforms.
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Bilirubin
Cayman ChemicalA yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase; has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions.
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Naringenin
Cayman ChemicalA citrus-derived flavonoid that inhibits CYP3A4 activity in human liver microsomes (IC50s = 139-188 μM); demonstrates antifibrotic, lipid lowering, and insulin-like properties.
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ß-Carotene
Cayman ChemicalA red/orange-colored fat-soluble terpenoid with antioxidant properties; can be cleaved to produce vitamin A and retinoic acid.
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Retinyl Acetate
Cayman ChemicalA natural form of vitamin A that is thermally more stable than retinol; can reduce cell proliferation and promote differentiation.
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Fenbendazole
Cayman ChemicalA broad-spectrum benzimidazole anthelmintic that is active against gastrointestinal parasites (IC50 = 0.30 µM against Giardia in vitro) by targeting tubulin; activates HIF-1α, abrogating oxidative stress-induced death in primary neurons in vitro.
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n-Dodecyl-ß-D-maltoside
Cayman ChemicalA non-ionic detergent commonly used to solubilize membrane-associated proteins; helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation.
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ß-D-Glucosamine Pentaacetate
Cayman ChemicalAn N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.
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Chlorhexidine (hydrochloride)
Cayman ChemicalAn an antimicrobial agent that is often used in antiseptics and dental products such as toothpaste and mouthwash; inhibits MMP-2, -8, and -9.
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Nitro Blue Tetrazolium (chloride)
Cayman ChemicalA chromogenic substrate that, like other tetrazolium compounds, can be reduced to produce a colored formazan derivative; used in the “NBT test” to evaluate the activity of NADPH oxidase in phagocytes; paired with PCIB for the colorimetric detection of alkaline phosphatase activity.
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Chrysin
Cayman ChemicalA natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties; inhibits HIF-1α expression in cancer cells; decreases pro-inflammatory gene expression and oxidative stress in ischemia/reperfusion injury.