Nicotinic acetylcholine receptor agonist isolated from Nicotiana tabacum and Nicotiana rustica. Nicotine Tartrate finds an application as the nicotine active in a wide range of smoking cessation products such as nicotine lozenges and nicotine sub-lingual tablets. (-)-Nicotine ditartrate is a…

Linoleic acid is a PUFA prevalent in the western diet. The peroxide free linoleic acid is protected from autoxidation by the antioxidant BHT (2,6-Di-tert-butyl-4-hydroxytoluene). Linoleic acid is also available without BHT (Item No. 90150).

An oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides.

An HDAC inhibitor of class I and class II HDACs at around 50 nM; arrests cell growth in a wide variety of transformed cells in culture at 2.5-5.0 µM.

A structural analog of sphingosine and a novel immune modulator; inhibits lymphocyte emigration from lymphoid organs; becomes phosphorylated by sphingosine kinase in vivo to act as a potent agonist at S1P1, S1P3, S1P4, and S1P5.

The oxidized form of NADPH; serves as a cofactor in various biological reactions.

A plant growth regulator involved in the signaling mechanisms for a variety of conditions including plant defense, wound healing, tuberization, fruit ripening, and senescence.

β-estradiol is a potent mammalian estrogenic hormone produced by the ovary. Triggers the production of gonadotropins leading to ovulation. β-Estradiol is used to study cell differentiation and transformations (tumorigenicity). The pharmacology and HPLC determination of β-Estradiol…

A non-protein amino acid that chelates iron and copper; inhibits certain enzymes that contain iron or copper, including arginase (IC₅₀ = 3.7 µM).

A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC₅₀ = 0.92 µg/ml) as well as topoisomerase IV (IC₅₀ = 1.62 µg/ml).

A naturally-occurring dimethyl ether analog of resveratrol; acts as a powerful antioxidant, suppresses the synthesis of PGE2 from LPS-stimulated human peripheral blood mononuclear cells (IC₅₀ = 1.0 μM), and inhibits cell proliferation (IC₅₀ = ~60 μM); evokes effects that…

An essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain; constitutes as much as 40% of the total PUFA pool in retinal and neuronal membranes; dietary supplementation via fish oil inhibits the progression of atherosclerosis and delays…

A benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.

An intermediate in the catabolism of aromatic amino acids; formed in excess during alkaptonuria.

A reversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase; blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM.

A platinum-containing compound that acts as an alkylating agent; used alone or in combination therapy in the treatment of several types of cancer; inhibits the RecA recombinase of M. tuberculosis (IC₅₀ = 2 µM), blocking protein splicing and cell growth.

A cell-permeable substrate for aminopeptidase M and leucine aminopeptidase that was developed for intracellular analysis of protease activities.

A synthetic intermediate useful for pharmaceutical synthesis.

A semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM); has applications in breast cancer and hormone-refractory prostate cancer; intended for research applications.

An anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively; displays chemopreventive activity in multiple tumor types via proapoptotic effects independent of its capacity to block COX-2.

An intermediate in the interconversion of glucose and galactose.

5-Bromotetralone is a synthetic intermediate useful for pharmaceutical synthesis.

An anti-inflammatory steroid.

A steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors; also is the precursor to aldosterone synthesis.

A selective activator of AMPK; inhibits synthesis of fatty acids and sterols in hepatocytes and insulin-stimulated glucose uptake in adipocytes.

A chromogenic substrate that, like other tetrazolium compounds, can be reduced to produce a colored formazan derivative; used in the “NBT test” to evaluate the activity of NADPH oxidase in phagocytes; paired with PCIB for the colorimetric detection of alkaline phosphatase activity.

A compound used to attach biotin to primary amines, such as lysines on the surface of proteins, under alkaline conditions (pH~8-9).

A non-depolarizing muscle relaxant that competitively blocks cholinergic receptors at the motor end plate of the neuromuscular junction, inducing temporary paralysis.

Pure Canavalia ensiformis lectin (Con A) from Jackbean. Isolated by affinity chromatography on cross-linked dextran. Con A exists as a dimer below pH 5.0 and and at pH >7 it exists as a tetramer. Con-A is not a glycoprotein. The monomeric molecular weight of Con-A is 25,500. Con-A does not…

A selective β-adrenoceptor agonist that shows high affinity for β1, β2, and β3 (Ki = 224, 458, and 1,570 nM, respectively); inhibits contractions in isolated field stimulated rat vas deferens at low concentrations (EC₅₀ = 45.6 nM); increases cAMP levels and can…

A fluorogenic substrate of β-glucuronidase that upon cleavage yields a blue fluorescent end product that can be monitored by UV light; typically used in the GUS reporter system for fluorescent detection of β-glucuronidase gene expression in E. coli and transformed plants.

An irreversible inhibitor of γ-glutamylcysteine synthetase (Ki limiting enzyme for GSH synthesis, that induces oxidative stress in cells by depleting GSH; enhances the toxicity of various chemotherapeutic agents in drug-resistant tumors.