Synonyms: tert-Butyl 4-((2-fluorophenyl)carbamoyl)-1,4-diazepane-1-carboxylate; SHI-8 Molecular Formula: C17H24FN3O3 Molecular Weight: 337.39 Linear Structural Formula: C17H24FN3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the…

Synonyms: tert-Butyl 4-(1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate; SHI-17 Molecular Formula: C14H22N4O3 Molecular Weight: 294.35 Linear Structural Formula: C14H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

A selective inhibitor of ABHD6 (IC₅₀ = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ; used both as a probe to study ABHD6 and as a negative control for studies of DAGLβ.

A cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors.

A polymethoxylated flavone that has been shown to enhance adipogenesis and lipolysis, to inhibit α-glucosidase and α-amylase activity, and to suppress the expression of genes associated with inflammation by regulating IκBα.

A glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase.

A protein cross-linking agent isolated from G. jasminoides Ellis; inhibits UCP2 activity; 5 µM genipin increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose; induces apoptosis in FaO rat hepatoma cells and human…

An alkaloid that inhibits the growth of mouse leukemia P388 cells (IC₅₀ = 1.8 μg/ml); binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC₅₀ = 5.07-12.6 μM); selectively inhibits CYP1A1 and CYP1A2 (IC50 = ~6 μM for…

Phosmet-(dimethyl-d6) is an isotope-labeled analog of the organophosphorus insecticide, phosmet, widely used for pest control in agriculture. Synonyms: Phosmet-d6 Molecular Formula: C11D6H6NO4PS2 Molecular Weight: 323.36 Linear Structural Formula: C11D6H6NO4PS2 MDL Number: …

Synonyms: 1,1'-Dimethyl-4,4'-bipyridinium-2,2',3,3',5,5',6,6'-d8 dichloride; Methyl viologen-d8 dichloride; Paraquat dichloride-d8 Molecular Formula: C12D8H6Cl2N2 · xH2O Linear Structural Formula: C12D8H6Cl2N2 · xH2O MDL Number: MFCD01074178 Purity: >=98.0% (HPLC) Storage: 2-8C…

A CYP2C9 metabolite of the NSAID diclofenac that demonstrates anti-inflammatory and analgesic properties by inhibiting COX and suppressing PGE2 synthesis.

Synonyms: tert-Butyl methyl(2-(N-methyl-1H-pyrazole-1-carboxamido)ethyl)carbamate; SHI-20 Molecular Formula: C13H22N4O3 Molecular Weight: 282.34 Linear Structural Formula: C13H22N4O3 Purity: >=95% Application: Serine hydrolase inhibitors are small molecule fragments that react…

Synonyms: tert-Butyl 4-((4-(trifluoromethyl)phenyl)carbamoyl)piperazine-1-carboxylate; SHI-4 Molecular Formula: C17H22F3N3O3 Molecular Weight: 373.37 Linear Structural Formula: C17H22F3N3O3 MDL Number: MFCD01763542 Application: Serine hydrolase inhibitors are small molecule…

A natural type B trichothecene produced by certain species of the fungus Fusarium; inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA; passes the blood-brain barrier at different rates in different animals.

Synonym(s): [2-(2,6-Dichloro-4-hydroxy-phenylamino)phenyl]acetic acid, 4'-OHD Formula: C14H11Cl2NO3 Formula weight: 312.15 CAS Number: 64118-84-9 UN Number: UN2811 Hazard Class: 6.1 Packing Group: III Harmonized Tariff Code:  2922.50 Hazard Statements: H301-H318-H315-H335 …

A synthetic prodrug which is converted to the vitamin D receptor agonist 1,25-dihydroxy vitamin D3 in vivo; suppresses the synthesis and secretion of parathyroid hormone in secondary hyperparathyroidism; supports bone growth; provides renal and cardiovascular protection during chronic kidney disease.

A selective allosteric inhibitor of Bcr-Abl (IC₅₀s = 4.52, 0.38, and 0.93 µM against Bcr-Abl mutants G250E, E255V, and M351T, respectively); displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse…

An analog of wortmannin; irreversibly binds PI3K; inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap cells (IC₅₀ = 1.46 μM).

Synonyms: 2-Phenyl-3-(4-hydroxyphenyl)-5,7-bis(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine; 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]-pyrimidin-3-yl]phenol Molecular Formula: C20H11F6N3O Molecular Weight: 423.31 Linear Structural Formula: C20H11F6N3O MDL Number: …

An intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3; plasma or serum levels are commonly used as an indicator of an individual’s vitamin D status.

An antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC₅₀ = ~24 μM); 8 μM treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold, respectively; 5 mg/kg inhibits mammary…

Synonyms: alpha,alpha-Dimethylphenethylamine hydrochloride; alpha-Benzylisopropylamine hydrochloride; 1,1-Dimethyl-2-phenylethylamine hydrochloride; 2-Methyl-1-phenylpropan-2-amine hydrochloride; 2-Phenyl-tert-butylamine hydrochloride; alpha,alpha-Dimethylphenethylamine hydrochloride Molecular…

A selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 (IC₅₀ = 22 nM).

Synonyms: 5-(4-Chloro-phenyl)-[3,3']bipyridinyl-6,6'-diamine dihydrochloride Molecular Formula: C16H13ClN4 · 2HCl Molecular Weight: 369.68 Linear Structural Formula: C16H13ClN4 · 2HCl Purity: >=98% (HPLC) Storage: room temp Biochem Physiol Actions: PF-06260933…

Empirical Formula: C₁₈H₂₅NO₅ Linear Formula: C₁₈H₂₅NO₅ Formula Weight: 335.39 MDL Number: MFCD00221720 Purity: ≥95.0% (GC) Melting Point: 236 °C(lit.) Storage: −20°C Beilstein Registry…

Synonyms: tert-Butyl 4-((4-(trifluoromethyl)phenyl)carbamoyl)-1,4-diazepane-1-carboxylate; SHI-5 Molecular Formula: C18H24F3N3O3 Molecular Weight: 387.4 Linear Structural Formula: C18H24F3N3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro…

Synonyms: 6-Amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide; 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-Pyridinecarboxamide; N-Methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide; PF 01247324; PF-1247324 Molecular Formula: C13H10Cl3N3O Molecular Weight: …

Synonyms: tert-Butyl 4-(1H-pyrazole-1-carbonyl)piperazine-1-carboxylate; SHI-14 Molecular Formula: C13H20N4O3 Molecular Weight: 280.32 Linear Structural Formula: C13H20N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

Synonyms: tert-Butyl 4-((2-fluorophenyl)carbamoyl)piperazine-1-carboxylate; SHI-7 Molecular Formula: C16H22FN3O3 Molecular Weight: 323.36 Linear Structural Formula: C16H22FN3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

Synonyms: tert-Butyl methyl(2-(1-methyl-3-(4-(trifluoromethyl)phenyl)ureido)ethyl)carbamate; SHI-6 Molecular Formula: C17H24F3N3O3 Molecular Weight: 375.39 Linear Structural Formula: C17H24F3N3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in…

Synonyms: tert-Butyl 4-(pyridin-2-ylcarbamoyl)piperazine-1-carboxylate; SHI-1 Molecular Formula: C15H22N4O3 Molecular Weight: 306.36 Linear Structural Formula: C15H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

Synonyms: tert-Butyl (2-(3-(2-fluorophenyl)-1-methylureido)ethyl)(methyl)carbamate; SHI-9 Molecular Formula: C16H24FN3O3 Molecular Weight: 325.38 Linear Structural Formula: C16H24FN3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with…