Chemicals, Bottle, Glass, Clear, UN1231
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Prostaglandin F2a-d4
Cayman ChemicalAn internal standard for the quantification of PGF2α by GC- or LC-MS.
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15(S)-Latanoprost
Cayman ChemicalAn analog of latanoprost in which the hydroxyl at C-15 is inverted relative to latanoprost; binds to the FP receptor in the cat iris sphincter muscle with an IC50 value of 24 µM (tested as the free acid); potential impurity in latanoprost bulk drug preparations.
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17-trans Prostaglandin E3
Cayman Chemical17-trans PGE3 is an isomer of PGE3 which could theoretically result from the COX metabolism of dietary trans-fatty acids. There are no published reports on the biological activity of this compound.
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15(R)-15-methyl Prostaglandin D2
Cayman ChemicalThe physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent,…
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17-phenyl trinor Prostaglandin A2
Cayman Chemical17-phenyl trinor PGA2 is a synthetic prostaglandin analog designed for increased half-life and greater potency. There are no published reports of the biological activity of 17-phenyl trinor PGA2 in the literature at this time.
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13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
Cayman ChemicalAn internal standard for quantification of 13,14-dihydro-15 (R,S)-hydroxy-16,16-difluoro-Prostaglandin E1, a metabolite of a bicyclic PGE1 derivative used in the treatment of chronic constipation, by GC- or LC-mass spectrometry (MS).
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17-phenyl trinor Prostaglandin F2a diethyl amide
Cayman ChemicalAn F-series PG analog in which the C-1 carboxyl group has been modified to an N-diethyl amide; dialkyl amides such as a 17-p-PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids.
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A1-Phytoprostane-I
Cayman ChemicalA cyclopentenone isoprostane produced by the action of reactive oxygen species on α-linolenic acid in plants; induces the expression of glutathione-S-transferase, increases phytoalexin biosynthesis, and triggers the expression of several genes involved in primary and secondary metabolism in plants.
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20-ethyl Prostaglandin E2
Cayman Chemical20-ethyl PGE2 is an analog of PGE2 in which the ω-chain has been extended by the addition of two methylene carbon atoms. The only well studied prostaglandin analog with this structural feature is unoprostone, an F-series prostaglandin that is clinically approved as a glaucoma medication.…
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13-OAHSA
Cayman ChemicalA form of FAHFA in which oleic acid is esterified to 13-hydroxy stearic acid.
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8-iso Prostaglandin A1
Cayman Chemical8-iso PGA1 is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.
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11ß-13,14-dihydro-15-keto Prostaglandin F2a
Cayman ChemicalA metabolite of PGD2 via the 15-hydroxy PGDH pathway.
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ent-Prostaglandin E2
Cayman ChemicalEnzymatically-derived PGE2 is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2. Significant amounts of racemic PGE2 (rac-PGE2) are generated in vitro and in vivo in settings…
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Fluprostenol isopropyl ester-d4
Cayman ChemicalAn internal standard for the quantification of fluprostenol isopropyl ester by GC- or LC-MS.
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Bicyclo Prostaglandin E2
Cayman ChemicalBicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml. Due to the inherent instability of 13,14-dihydro-15-keto PGE2, it is advisable to quantify…
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15(R)-Prostaglandin F2a
Cayman Chemical15(R)-PGF2α is the C-15 epimer of the naturally occurring mammalian autacoid PGF2α. It has only 25% of the potency of PGF2α in hamster antifertility studies, which may be due to reduced affinity for FP receptors. Compared to PGF2α, 15(R)-PGF2α has a binding affinity of…
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15(R)-17-phenyl trinor Prostaglandin F2a isopropyl ester
Cayman ChemicalA latanoprost-related isomer containing both a double bond at C-13,14 and an invered (b) hydroxyl group at C-15; a potential impurity in most commercial preparations of the lantanoprost bulk drug product.
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Prostaglandin E2-d9
Cayman ChemicalAn internal standard for the quantification of PGE2 by GC- or LC-MS.
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Methyl a-Linolenyl Fluorophosphonate
Cayman ChemicalAn analog of MAFP, which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand; pharmacology of the α-linolenyl analog of MAFP has not been completely investigated.
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Unoprostone isopropyl ester
Cayman ChemicalUnoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of PGF2α. Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate…
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Latanoprost (free acid)-d4
Cayman ChemicalAn internal standard for the quantification of latanoprost (free acid) by GC- or LC-MS.
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16,16-dimethyl Prostaglandin E2
Cayman ChemicalA competitive inhibitor of 15-hydroxy PGDH; acts as an agonist on most EP receptor subtypes (Kd d~ 1 nM for isolated EP2 receptors); preserves the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.
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13,14-dihydro-15-keto Prostaglandin F2a
Cayman ChemicalProminent plasma metabolite of PGF2α in the 15-hydroxy PGDH pathway.
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9-POHSA
Cayman ChemicalA FAHFA consisting of palmitoleic acid esterified at the 9-position of hydroxy stearic acid; significantly elevated in serum of glucose tolerant AG4OX mice; may be a bioactive lipid with roles in metabolic syndrome and inflammation.
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15(S)-15-methyl Prostaglandin E2
Cayman Chemical15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.
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Clasto-Lactacystin ß-lactone
Cayman ChemicalActive metabolite of lactacystin, a widely used selective inhibitor of the 20S proteasome, with at least 10 times better activity; irreversibly alkylates subunit X of the 20S proteasome.
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Prostaglandin F2a ethyl amide
Cayman ChemicalPGF2α-NEt is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been…
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8-iso-15-keto Prostaglandin F2ß
Cayman ChemicalA potential metabolite of 8-iso PGF2β via the 15-hydroxy PGDH pathway.
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8-iso-17-phenyl trinor Prostaglandin F2ß
Cayman Chemical8-iso-17-phenyl PGF2β is an isomer of bimatoprost (free acid) that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2β.