A mycotoxin produced by Alternaria molds; induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells (20-40 μM).

Alternariol is a mycotoxin initially produced by species of Alternaria. Alternariol produces a weak estrogenic response in vitro and increases production of estradiol and progesterone. Alternariol is also cytotoxic; in macrophages, it increases DNA base oxidations and strand breaks. Also in…