A non-selective NSAID exhibiting IC50 values of 0.5 and 2.33 µM for human recombinant COX-1 and COX-2, respectively.

(S)-Naproxen is a non-selective COX inhibitor. The IC₅₀ values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively.

Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper. Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in…

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension. At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats. The…

A flavonoid compound found in the bark and rinds of many plants and fruits.

An NSAID thought to exert its actions by a prostanoid-independent mechanism; inhibits fMLP- and A23187-induced Ca2+ influx in human neutrophils with an IC₅₀ value of approximately 20 µM.

Niflumic acid is a selective inhibitor of COX-2. The IC₅₀ values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively. The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.

Ketorolac is a non-selective COX inhibitor. The IC₅₀ values for human recombinant COX-1 and -2 are 31.5 µM and 60.5 µM, respectively.

Nimesulide is a selective inhibitor of COX-2. The IC₅₀ values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.

A non-selective COX inhibitor; inhibits human recombinant COX-1 and -2 with IC₅₀ values of 0.04 and 0.51 µM, respectively.

A non-selective inhibitor of both COX-1 and COX-2 with extensive epidemiology documenting its effective reduction of human colorectal cancer.

A derivative of aminoacridine that functions as an inhibitor of both AChE and butyrylcholinesterase; used clinically in the treatment of Alzheimer’s disease; inhibits the uptake of serotonin and noradrenaline in rat cerebral cortex and decreases depolarization-induced calcium influx through…