A nitrogen mustard β-chloro-nitrosourea compound used as an alkylating agent to form interstrand crosslinks in DNA, which leads to cancer cell cytotoxity and apoptosis; also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase.

Carmustine is a nitrosourea alkylator that is clinically used to treat brain cancers, multiple myeloma, and lymphomas. Carmustine exhibits anticancer chemotherapeutic and anticoagulant activities. Carmustine is often co-administered with MGMT inhibitors to increase its chemotherapeutic efficacy. In…