Baclofen is a GABA derivative that acts as an agonist at GABA-B receptors; it is commonly used in animal models to examine the effects of GABAergic neurotransmission in a variety of fields, including substance dependence, spasticity, pain, and feeding behavior. Baclofen exhibits analgesic,…

A selective agonist of GABAB (IC₅₀ = 200 nM); causes skeletal muscle relaxation and blocks spasticity.