An antagonist of VEGFR1, VEGFR2, and VEGFR3 with IC₅₀ values of 77, 37, and 190 nM, respectively; less potently inhibits PDGF and c-Kit (IC₅₀ = 600 and 700 nM) and has no effect on additional kinases; completely blocks retinal neovascularization in oxygen-induced ischemic…