Biologically Active Small Molecules, 500 mg, NEW! Life Science
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Artemisinin
Cayman ChemicalA natural product which effectively kills malarial parasites of the genus Plasmodium (IC50 = 4.0 nM); also used against a wide range of trematodes, including Schistosoma; has potential applications in certain types of cancer and inflammatory conditions.
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5-Bromotetralone
Cayman Chemical5-Bromotetralone is a synthetic intermediate useful for pharmaceutical synthesis.
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Suberohydroxamic Acid
Cayman ChemicalA competitive HDAC inhibitor that inhibits HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM); causes cell differentiation, cell cycle arrest, or apoptosis.
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Carprofen
Cayman ChemicalAn NSAID commonly used in animals to combat pain and inflammation, particularly as associated with osteoarthritis; inhibits both COX-1 and COX-2 (IC50s = 22.3 and 3.9 µM, respectively) and also FAAH (IC50 = 74 µM).
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Dexamethasone
Cayman ChemicalA synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 vs. 17 nM, respectively); has anti-inflammatory effects.
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Cisplatin
LKT LabsCisplatin is a platinum-based cross-linking agent that exhibits anticancer chemotherapeutic activity. Cisplatin induces crosslinks between guanine bases on DNA; it is clinically used to treat various forms of cancer. In lung cancer cells, cisplatin decreases phosphorylation of PI3K, Akt, and FOXO3a…
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Imiquimod
Cayman ChemicalAn imidazoquinoline compound that activates TLR7 (EC50 = 2.1 µM) on immune cells, inducing the production of IFN-α, IL-12, and other mediators; up-regulates the OGF receptor on cancer cells, blocking cell proliferation (IC50 = 2 µM).
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Tamoxifen
Cayman ChemicalA selective estrogen receptor (ER) modulator; an ER antagonist in breast tissue, effective in treating early breast cancer; an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues.
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3,3'-Diindolylmethane
Cayman ChemicalPhytochemical from cruciferous vegetables that demonstrates anticancer and chemopreventative effects (10-30 µM) involving the induction of Phase 2 enzymes, promotion of apoptosis, induction of cell cycle arrest, inhibition of cell proliferation, and inhibition of histone deacetylases and DNA…
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Concanavalin A from Canavalia ensiformis seeds (jack beans)
MP BiomedicalsPure Canavalia ensiformis lectin (Con A) from Jackbean. Isolated by affinity chromatography on cross-linked dextran. Con A exists as a dimer below pH 5.0 and and at pH >7 it exists as a tetramer. Con-A is not a glycoprotein. The monomeric molecular weight of Con-A is 25,500. Con-A does not…
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Hoechst 33342 (hydrochloride)
Cayman ChemicalA cell-permeable, fluorescent probe for DNA that is useful as a marker of nuclei for cell cycle studies in combination with BrdU and to distinguish nuclear morphology in apoptotic cells.
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1,6-Anhydro-ß-D-mannopyranose
Cayman ChemicalA major organic tracer generated by burned cellulose; used to evaluate, in atmospheric samples, the burning of wood.
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Clinafloxacin (hydrochloride)
Cayman ChemicalA fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml).
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Lenalidomide
Cayman ChemicalAn analog of thalidomide that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines; induces proliferation and enhances the functional capacity of T-lymphocytes, amplifying co-stimulatory signaling pathways.
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Leflunomide
Cayman ChemicalA prodrug for A-771726 that regulates T lymphocyte progression through the cell cycle by selectively inhibiting de novo pyrimidine synthesis; used to slow the disease progression of rheumatoid arthritis and as an immunosuppressive agent to prevent rejection of transplant allografts and xenografts.
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Amiodarone (hydrochloride)
Cayman ChemicalA class III antiarrhythmic agent; inhibits KCNH2 with an IC50 value of 1 µM; also inhibits CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.
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Nitro Blue Tetrazolium (chloride)
Cayman ChemicalA chromogenic substrate that, like other tetrazolium compounds, can be reduced to produce a colored formazan derivative; used in the “NBT test” to evaluate the activity of NADPH oxidase in phagocytes; paired with PCIB for the colorimetric detection of alkaline phosphatase activity.
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3,4,6-Tri-O-benzyl-ß-D-Mannopyranose 1,2-(methyl orthoacetate)
Cayman ChemicalA synthetic intermediate used in glycosylation reactions.
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Nitrendipine
Cayman ChemicalA dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels; also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively.
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2-tert-Butyl-4-Hydroxyanisole
LKT Labs2-Tert-butyl-4-hydroxyanisole (2-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative activity. 2-BHA acts as a phase II enzyme inducer, increasing levels of glutathione and glutathione-S-transferase.
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Tobramycin
Cayman ChemicalAn aminoglycoside antibiotic that shows potent activity against a broad spectrum of bacteria.
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1-thio-ß-D-Glucose (sodium salt)
Cayman ChemicalAn analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position, allowing diverse chemical reactions, including click chemistry and polymerization; can be labeled with technetium-99m for analytical and diagnostic procedures.
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CAY10512
Cayman ChemicalCAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.
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Stearic Acid
Cayman ChemicalA long-chain saturated fatty acid that does not affect plasma total cholesterol or LDL-cholesterol but may reduce HDL-cholesterol.
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2-(hydroxymethyl)-Pyrimidine
Cayman Chemical2-(hydroxymethyl)-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.
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a-D-Galactose-1-phosphate (potassium salt)
Cayman ChemicalAn intermediate in the interconversion of glucose and galactose.
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N-Octyl-ß-D-thioglucopyranoside
Cayman ChemicalA low molecular weight nonionic detergent that is commonly used for cell lysis and non-denaturing protein solubilization.
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Pargyline (hydrochloride)
Cayman ChemicalPargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension. At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats. The…
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(S)-10-hydroxy-Camptothecin
Cayman ChemicalAn inhibitor of topoisomerase I that demonstrates less toxicity than its parent compound; demonstrates strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM).
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Gly-Phe-ß-naphthylamide
Cayman ChemicalA substrate of cathepsin C that accumulates inside lysosomes causing lysosome degradation; 50 μM can inhibit the cathepsin-dependent activation of caspase-8.
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Hexanoyl Glycine
Cayman ChemicalAn acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation.