A first generation histamine H1 receptor antagonist (Ki = 2.6 nM) that also inhibits muscarinic acetylcholine receptors (Ki = 22 nM); penetrates the CNS, depressing central H1 receptor activity, which may relate to its sedative properties.

A selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively; at 10 µM, blocks the hydrolysis of cis- and trans-EETs and completely inhibits 14,(15)-EET-induced PPAR activation.