An analog of geldanamycin which has potent in vivo activity and reduced toxicity; has diverse anti-tumor actions; promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50 = 4-72 nM).

An intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids; also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.

α-ESA is a conjugated PUFA commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown…

An α-sulphonated version of arachidonic acid that may possess improved lipophilicity.

A C-7 truncated analog of LXA4 that is equiactive as LXA2 in the inhibition of LTB4-induced neutrophil chemotaxis (IC50 = 5 nM).

An optically active isomer of TBP-OH, a compound produced from the metabolism of the organophosphorus solvent, TBP.

An intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols; also serves as a donor in post-translational isoprenylation of proteins.

A PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC₅₀ = 2.5 µM); reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.

Inhibits PAD4 activity (IC50 = 21.6 μM) as well as PAD1 and PAD3 activity (IC50s = 29.5 and 350 μM, respectively); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

A selective and potent ROCK inhibitor (IC₅₀ = 11.8 nM for ROCK-II); poorly inhibits CaMKII, protein kinase G, and Aurora A (IC₅₀ = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC₅₀ ≥ 10 μM for each).

A prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling; may activate TRPV1 and TRPV4.

A selective PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC₅₀ = 3.7 µM); reversibly blocks the production of glucose-derived serine in cells.

A potent inhibitor of Nampt (IC₅₀ = 3 nM); induces cell death in the neuroblastoma cell line SH-SY5Y with an IC₅₀ value of 3.8 nM through a process that appears to involve autophagy.