A thioester substrate analog of 2-AG that can be utilized for the measurement of MAGL activity; hydrolysis of the thioester bond by MAGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB resulting in a yellow product with an absorbance maximum at 412 nm.

A form of DAG where both acyl groups consist of the 18:1 oleoyl chain; binds the C1 domain and activates conventional PKC forms and serves as a substrate for diacylglycero kinases and multisubstrate lipid kinase.

An analog of DAG, which inhibits the activation of PKC by DAG.

A congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group that potentiates the activity of other endocannabinoids, including 2-AG; this “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to rapidly reduce…

A HSL member that is produced by the F2/5 strain of A. vitis, the bacterium responsible for grape crown gall and its resulting loss of agricultural productivity.

OAG is a cell-permeable analog of the PKC-activating second messenger DAG. It activates PKC in platelets, resulting in the phosphorylation of a 40 kDa protein. OAG is metabolized to its corresponding phosphatidic acid (1-oleoyl-2-acetyl-3-phosphoglycerol), most likely through the action of a…

A fatty acid glycerol that has been isolated from S. chinensis roots, inhibits PAF-AH with an IC50 value of 45 µM.

An endogenous CB receptor ligand that is 10-100 times less potent than 2-AG in ligand binding affinity and agonist activity at the CB1 receptor; 2-AG undergoes rapid isomerization to 1-AG, which makes it a frequent contaminant in synthetic 2-AG preparations, markedly reducing their cannabinergic potency.

An analog of the PKC-activating second messengers collectively called DAG; equipotent to 1,2-dioctanoyl-sn-glycerol in induction of the acrosome reaction in human sperm.

A potent and selective inhibitor of HDAC6 (IC₅₀ = 36 nM) that poorly blocks other HDAC enzymes; cell permeable, inhibiting the acetylation of tubulin in cells with an IC₅₀ value of 210 nM.

An endogenous agonist of the CB1 and CB2 receptors; it is the most abundant molecular species of monoacylglycerol found in rat brain.

A bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity.