Biologically Active Small Molecules, 10 g, UN3077
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Promethazine (hydrochloride)
Cayman ChemicalA first generation histamine H1 receptor antagonist (Ki = 2.6 nM) that also inhibits muscarinic acetylcholine receptors (Ki = 22 nM); penetrates the CNS, depressing central H1 receptor activity, which may relate to its sedative properties.
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N,N'-Dicyclohexylurea
Cayman ChemicalA selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively; at 10 µM, blocks the hydrolysis of cis- and trans-EETs and completely inhibits 14,(15)-EET-induced PPAR activation.
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Candesartan cilexetil
Cayman ChemicalA prodrug of the potent, long-acting, and selective AT1 receptor antagonist, candesartan; 4-16 mg/day effectively reduces diastolic blood pressure and has proved useful in the treatment of hypertension and diabetes.