A calcimimetic that allosterically activates the calcium-sensing receptor (CaSR; pEC₅₀ = 7.3 in HEK293T cells expressing CaSR) inhibiting parathyroid hormone secretion.

Cinacalcet is an agonist at Ca2+-sensing receptors that is clinically used to treat secondary hyperparathyroidism with chronic kidney disease. Cinacalcet also displays anti-fibrotic activity. This compound decreases levels of parathyroid hormone (PTH), increases adiponectin secretion, and lowers…