Active metabolite of lactacystin, a widely used selective inhibitor of the 20S proteasome, with at least 10 times better activity; irreversibly alkylates subunit X of the 20S proteasome.

An internal standard for the quantification of CAY10429 by GC- or LC-MS.

An internal standard for the quantification of PGF2α by GC- or LC-MS.

Contains four deuterium atoms at the 3', 3', 4', and 4' positions; is intended for use as an internal standard for the quantification of tafluprost by GC-or LC-mass spectrometry.

An internal standard for the quantification of PGA2 by GC- or LC-MS.

A metabolite of PGD2 via the 15-hydroxy PGDH pathway.

An internal standard for the quantification of 5-POHSA by GC- or LC-MS.

A major urinary metabolite of PGE2 that is excreted in guinea pig urine at a concentration range of 1.34-2.74.

An internal standard for quantification of 13,14-dihydro-15 (R,S)-hydroxy-16,16-difluoro-Prostaglandin E1, a metabolite of a bicyclic PGE1 derivative used in the treatment of chronic constipation, by GC- or LC-mass spectrometry (MS).

A potential metabolite of 8-iso PGF2β via the 15-hydroxy PGDH pathway.

17-trans PGE3 is an isomer of PGE3 which could theoretically result from the COX metabolism of dietary trans-fatty acids. There are no published reports on the biological activity of this compound.

8-iso PGA1 is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.

A dehydration product of tetranor-PGEM that can be measured as a surrogate for tetranor-PGEM levels in urine.

8-iso-17-phenyl PGF2β is an isomer of bimatoprost (free acid) that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2β.

A metabolite of (±)12(13)-EpOME.

An internal standard for the quantification of 4-hydroxy hexenal by GC- or LC-MS.

8-iso PGF1α-d9 contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8-iso PGF1α by GC- or LC-MS.

Fluprostenol-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of fluprostenol by GC- or LC-MS.

8-iso-15-keto PGF2α is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted…

13,14-dh-15-k PGE1-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh-15-k PGE1 by GC- or LC-mass spectrometry.

An internal standard for the quantification of PGB2 by GC- or LC-MS.

An internal standard for the quantification of 5(Z),8(Z),11(Z)-eicosatrienoic acid by GC- or LC-MS.

Contains four deuterium atoms at the 3', 3', 4', and 4' positions; is intended for use as an internal standard for the quantification of tafluprost (free acid) by GC-or LC-mass spectrometry.

An expected J-ring, urinary PGD2 metabolite that may serve as a useful control in the analysis of PGD2 biosynthesis.

Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis. The mean plasma…

PGB3 is a non-enzymatic dehydration product resulting from the treatment of PGE3 with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARγ, PGB3 exhibited a Ki value greater than 1 mM.{11138} In contrast, PGB1 and PGB2 showed…

An internal standard for the quantification of 8-iso PGF2α by GC- or LC-MS.

(±)12(13)-EpOME is the 12,13-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. The toxicity and biosynthesis of (±)12(13)-EpOME have not been well differentiated from (±)9(10)-EpOME, but have been presumed to be essentially the same.

An internal standard for the quantification of BEL by GC- or LC-MS.

The opposite enantiomer of corey PG-lactone diol, a versatile, chiral intermediate used in the preparation of PGs and PG analogs.

An internal standard for the quantification of PGD1 by GC- or LC-MS.

(±)12(13)-EpOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-MS.