Pinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.

13(Z)-Docosenoic acid is a 22-carbon monounsaturated fatty acid. It is found predominantly in canola oil. 13(Z)-Docosenoic acid is metabolized to oleic acid in vivo. Diets rich in 13(Z)-docosenoic acid were shown to cause heart lipidosis in experimental animals. The C-1 amide of docosenoic acid has…

An uncommon, naturally occurring PUFA, inhibits the binding of [3H]-LTB4 to porcine neutrophil membranes with a Ki value of 3 µM.

An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor; in vivo activity is enhanced much less than the binding affinity, because it is rapidly hydrolyzed by FAAH.

3,4-Dihydroxyphenyl ethanol is a phenolic component of olive oil that inhibits both 12- and 5-LO. The IC₅₀ values for the inhibition of rat platelet 12-LO and rat neutrophil 5-LO are 4.2 and 13 µM, respectively. It does not inhibit, and may actually enhance, COX activity.…

A more lipid-soluble form of EPA.

A monounsaturated long chain fatty acid with potential antitumor and p53 inhibitory activity.

Linoleic acid is a PUFA prevalent in the western diet. The peroxide free linoleic acid is protected from autoxidation by the antioxidant BHT (2,6-Di-tert-butyl-4-hydroxytoluene). Linoleic acid is also available without BHT (Item No. 90150).

A simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine that was prepared as a mechanism for enhancing CNS dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier; increased CNS dopamine…

Mono-unsaturated fatty acids are components of the cellular membranes of autotrophic bacteria. The specific composition and abundance of membrane fatty acids can be used to identify specific genera of bacterial populations in natural environments (e.g., mining lakes, etc.). cis-7-Hexadecenoic acid…

A naturally occurring trans-fatty acid found in ruminant animals that is converted to 9(Z),11(E)-conjugated linoleic acid in mammals; reported to have beneficial antioxidant, anti-atherosclerotic, and antitumor activities.

A structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus, and the amide of vanillylamine and oleic acid; acts as an agonist at TRPV1, inducing desensitization analgesia in rat and mouse models of pain; potentiates the agonist activity of…

A synthetic analog of natural PC species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone.

Ethyl palmitoleate is a more lipophilic form of the free acid. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar cell injury due to excessive consumption of ethanol. Ethyl palmitoleate (10-100 µM) in addition to 850 mM ethanol…

An odoriferous component of musk that has been shown to exhibit anti-inflammatory effects by reducing the expression of proinflammatory cytokines both in vitro and in vivo; also reported to be both cardioprotective and neuroprotective during conditions of ischemia and to promote proliferation and…

A chromogenic PLA2 substrate that contains an ether-linked saturated C16 moiety at the sn-1 position and a thiol ester at the sn-2 position.

EPA is an ω-3 fatty acid abundantly available in marine organisms. Peroxide free EPA has been chromatographed under scrupulously oxygen free conditions to insure the removal of all contaminating fatty acid peroxides. The peroxide free EPA is protected from autoxidation by the antioxidant BHT…

Arachidonic acid is the keystone essential fatty acid at the origin of the arachidonic acid cascade. It is converted by cyclooxygenase, lipoxygenase, and epoxygenase enzymes into more than one hundred fifty different potent primary autacoid metabolites in species ranging from fungi to plants to…

Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

An unsaturated diacylglycerol with linoleic acid (18:2) side-chains attached at both the C-1 and C-3 positions that is useful for lipid research.

The stabilized ethyl ester form of DHA; dietary intake enhances maze-learning in mice; in rats it increases fatty acid oxidation enzymes and in humans with peroxisomal disorders it improves vision, liver function, and muscle tone; may directly modulate the actions of enzymes involved in fatty acid metabolism.

A 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail.

An analog of oleic acid in which the COOH group is replaced by trifluoromethyl ketone; it’s a potent inhibitor of FAAH, in both human and rat; in transfected COS-7 cells, 10 µM OTK inhibits 95.7% of human FAAH activity and 94.8% of rat FAAH activity.

Oleic acid ethyl ester is a neutral, more lipid-soluble form of oleic acid.

The amide of the neurotransmitter dopamine and arachidonic acid; a CB1-selective agonist that induces hypothermia, analgesia, catalepsy, and hypomotility in rats; a full agonist at TRPV1, but inactive at the dopaminergic D1 and D2 receptors; a potent inhibitor (IC₅₀ = 0.25 µM) of…

An isothiocyanate derived from cruciferous vegetables that has significant antiapoptotic and antioxidant effects in various cancer cells.

A selective CB2 receptor ligand with Ki values of 0.47 and 0.081 µM for human CB1 and CB2 receptors, respectively.

Linoleic acid ethyl ester is a neutral, lipid-soluble form of linoleic acid.

A competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).

An analog of bimatoprost.

A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.

γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53%…