Biologically Active Small Molecules, Cayman Chemical, 100 µg
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(±)14(15)-EpEDE
Cayman ChemicalAn EpEDE acid formed from DGLA, either by a strong oxidizing agent or by cytochrome P450 epoxygenases; biological properties are poorly understood.
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5(Z),11(Z),14(Z)-Eicosatrienoic Acid
Cayman Chemical5(Z),11(Z),14(Z)-Eicosatrienoic acid is a PUFA found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A diet containing MPSO lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was…
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Oleoyl Ethanolamide-d4
Cayman ChemicalAn internal standard for the quantification of OEA by GC- or LC-MS.
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(±)13(14)-EpDPA
Cayman ChemicalA DHA epoxygenase metabolite found in rat brain and spinal cord that acts as a preferred substrate for sEH (Km = 3.2 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays.
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trans-Resveratrol-d4
Cayman ChemicalAn internal standard for the quantification of trans-resveratrol by GC- or LC-MS.
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PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt)
Cayman ChemicalA synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.
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Cylindrospermopsin
Cayman ChemicalA cyanobacterial toxin that targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), inhibits uridine monophosphate synthase complex activity (Ki = 10 µM), and induces DNA damage.
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Resolvin E1
Cayman ChemicalA proposed anti-inflammatory EPA metabolite that has been shown to promote inflammatory resolution in numerous disease models, including experimental colitis, asthma, atherosclerosis, type 2 diabetes, and HSV-1-induced stromal keratitis.
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tetranor-PGDM
Cayman ChemicalA major metabolite of PGD2 found in human and mouse urine at levels of approximately 1.5 and 8.1 ng/mg creatinine, respectively.
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(±)12-HpETE
Cayman Chemical(±)12-HpETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (Item No. 90010) and consists of an equal mixture of the R and S isomers. Reduction of the hydroperoxide yields the more stable hydroxyl fatty acid (±)12-HETE (Item…
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13,14-dihydro-15-keto-tetranor Prostaglandin F1ß
Cayman ChemicalA major urinary metabolite of PGE2 that is excreted in guinea pig urine at a concentration range of 1.34-2.74.
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8(S)-HETrE
Cayman Chemical8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.
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Lactacystin
Cayman ChemicalA microbial metabolite isolated from Streptomyces that is widely used as a selective inhibitor of the 20S proteasome.
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2-Arachidonoyl Glycerol-d5
Cayman ChemicalAn internal standard for the quantification of 2-AG by GC- or LC-MS.
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Maresin 2
Cayman ChemicalA 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-LO and sEH co-incubated with DHA; reduces neutrophil infiltration in a mouse model of peritonitis and enhances human macrophage phagocytosis of zymosan A.
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2,3-dinor-11ß-Prostaglandin F2a
Cayman ChemicalKey urinary metabolite of PGD2; represents approximately 1% and 4% of the infused radiolabeled dose in monkeys and humans, respectively.
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(±)11(12)-EpETE
Cayman ChemicalAn epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo; its effects of remain to be determined.
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tetranor-12(S)-HETE
Cayman ChemicalMajor β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE
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15(R)-Lipoxin A4
Cayman ChemicalAn aspirin-triggered lipoxin that inhibits LTB4-induced chemotaxis, adherence, and transmigration of the neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.
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L-myo-Inositol-1,4,5-triphosphate (sodium salt)
Cayman ChemicalThe L isomer of the biologically important D-myo-inositol-1,4,5-triphosphate; does not evoke a rise in intracellular calcium when added to cells.
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Docosahexaenoic Acid-d5
Cayman ChemicalAn internal standard for the quantification of DHA by GC- or LC-MS.
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11-trans Leukotriene C4
Cayman Chemical11-trans LTC4 is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in…
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Carbocyclic Thromboxane A2
Cayman ChemicalA stable analog of TXA2; unlike other TP receptor agonists, it inhibits platelet aggregation (IC50 = 4-5 µM).
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(±)11-HDHA
Cayman Chemical(±)11-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets.…
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6-trans Leukotriene B4
Cayman ChemicalA non-enzymatic hydrolysis product of LTA4 with reduced activity compared to LTB4; also produced by oxidative decomposition of CysLTs such as LTC4 in the presence of myeloperoxidase and hypochlorous acid.
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PtdIns-(1,2-dihexanoyl) (sodium salt)
Cayman ChemicalA synthetic analog of natural PtdIns containing C6:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.
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D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)
Cayman ChemicalLargely acts a cell signaling intermediate; serving as substrate to produce IP5s, which can be further phosphorylated to produce Ins(1,2,3,4,5,6-)P6; also phosphorylated to produce phytic acid, which serves diverse roles in eukaryotic tissues; a poor activator of the Ins(1,4,5)-P3 receptor in vitro.
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8-iso-17-phenyl trinor Prostaglandin F2ß
Cayman Chemical8-iso-17-phenyl PGF2β is an isomer of bimatoprost (free acid) that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2β.
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(±)14(15)-EpEDE methyl ester
Cayman ChemicalAn analog of (±)14(15)-EpEDE with greater lipid solubility than the free base.
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13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
Cayman ChemicalAn internal standard for quantification of 13,14-dihydro-15 (R,S)-hydroxy-16,16-difluoro-Prostaglandin E1, a metabolite of a bicyclic PGE1 derivative used in the treatment of chronic constipation, by GC- or LC-mass spectrometry (MS).
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Lipoxin B4
Cayman ChemicalA positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes; inhibits PMV migration stimulated by LTB4 at a concentration of 10-7 M and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 x 10-10 M.
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D-myo-Inositol-2,3,5,6-tetraphosphate (sodium salt)
Cayman ChemicalProduced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K. terrigena; moderately effective in opening calcium channels relative to Ins(1,4,5)P3.