An inhibitor of Raf-1 and B-Raf (IC50 = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50 = 90, 15, 20, 57, and 58 nM, respectively); inhibits tumor angiogenesis and induces tumor cell apoptosis, particularly in…