Biologically Active Small Molecules, Cayman Chemical, 1166227-08-2, 1 mg

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1 mg 1166227-08-2 Cayman Chemical Biologically Active Small Molecules

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  • Cayman Chemical

    A-66 is a potent, selective inhibitor of the PI3K isoform p110α (IC50 = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110α over other isoforms. A-66 is effective in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice. It also impairs all…