Biologically Active Small Molecules, 6823-69-4, Chemicals
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GW 4869 (hydrochloride hydrate)
Cayman ChemicalA cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM), that does not affect acid sphingomyelinase activity; inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF-7 cells.
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