Biologically Active Small Molecules, 67-99-2
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Gliotoxin
Cayman ChemicalAn immunosuppressive mycotoxin which inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM), preventing activation of NF-κB; induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils; inhibits geranylgeranyltransferase I and farnesyltransferase (IC50…
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