Cholecalciferol (vitamin D3) is an endogenous prodrug of calcifediol; cholecalciferol is synthesized in the skin under UV-B exposure. Cholecalciferol supplements are occasionally used to prevent bone loss. D vitamins commonly exhibit anti-osteoporotic, immunomodulatory, anti-inflammatory, and…

An intermediate form of vitamin D which is obtained from dietary sources, such as fish, or through the conversion of 7-dehydrocholesterol by ultraviolet light; metabolized to the active form 1,25-dihydroxyvitamin D3 by CYP450 isoforms in the liver.