Biologically Active Small Molecules, 374922-43-7
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CAY10602
Cayman ChemicalDerived from HTS for compounds that increase the SIRT1-mediated deacetylation of a SIRT1-specific substrate; dose-dependently suppresses the NF-κB-dependent induction of TNF-α by LPS in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
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