A natural, nicotine-related alkaloid that binds the same receptor as nicotine, the nicotinic acetylcholine α4β2 subtype (Ki = 38 nM) and increases nicotine-induced hyperactivity, sensitization, and intravenous self-administration.

Anabasine is an alkaloid originally found in species of Nicotiana; it is a structural isomer of nicotine. Anabasine inhibits aromatase and nicotinic acetylcholine receptors (nAChRs) and may produce a depolarizing neuromuscular junction (NMJ) block. Anabasine can also be used as a clinical biomarker…