A staurosporine analog that potently inhibits JAK2 kinase (IC₅₀ = 1 nM) and downstream targets STAT5 (IC₅₀ = 10-30 nM) and STAT3 in a human erythroleukemic cell line expressing the JAK2V617F mutation; potently inhibits the epigenetic kinase PRK1 (PKN1) in vitro…