SouthernBiotech Primary Antibodies
-
SouthernBiotech Rat Anti-Mouse CD24-UNLB
SouthernBiotechCD24 is expressed in B cells until their terminal differentiation into plasma cells. It has been used widely as a marker to fractionate different B-lineage differentiation stages. CD24 has been found on a variety of other hematopoietic and neural cell types and is now classified as a costimulatory…
-
SouthernBiotech Hamster Anti-Mouse CD28-UNLB
SouthernBiotechCD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4+ and CD8+ peripheral T lymphocytes and at very low levels on NK cells. Its expression is upregulated upon T-cell activation. CD28 is a ligand for CD80 (B7-1) and CD86…
-
SouthernBiotech Hamster Anti-Mouse TCRgd-BIOT
SouthernBiotechThe TCR?d heterodimer of the CD3/T cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. It is expressed during thymopoiesis and on the small subpopulation of ?d TCR-expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial…
-
SouthernBiotech Rat anti-Mouse CD40-BIOT
SouthernBiotechCD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first…
-
SouthernBiotech Rat Anti-Mouse CD25-PE/CY7
SouthernBiotechThe IL-2 receptor (IL-2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity a chain of the IL-2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O-linked carbohydrates and has a short…
-
SouthernBiotech Hamster Anti-Mouse CD79b-LE/AF
SouthernBiotechMurine CD79 is a disulfide-linked heterodimer composed of an a chain (CD79a) and a ß chain (CD79b) that associates non-covalently with membrane immunoglobulin (Ig) to form the B cell receptor (BCR) complex. Its expression is restricted to B lymphocytes first appearing on the surface at the pro-B…
-
SouthernBiotech Rat Anti-Mouse CD25-AF700
SouthernBiotechThe IL-2 receptor (IL-2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity a chain of the IL-2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O-linked carbohydrates and has a short…
-
SouthernBiotech Rat Anti-Mouse CD38-FITC
SouthernBiotechMurine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral…
-
SouthernBiotech Rat Anti-Mouse CD45RB-BIOT
SouthernBiotechCD45RB represents an exon B-dependent form of CD45 glycoprotein. It is expressed at high density on peripheral B cells, the suppressor/cytotoxic subpopulation of T lymphocytes, a subset of helper T cells, most thymocytes, and at low density on macrophages and dendritic cells.
-
SouthernBiotech Rat Anti-Mouse CD45R-CY5
SouthernBiotechCD45R, also known as B220, a member of the protein tyrosine phosphate family and a major cell surface glycoprotein, represents a restricted form of the CD45 family which primarily recognizes only cells of B-lineage from pro-B cell through mature B lymphocytes and prior to the availability of…
-
SouthernBiotech Rat Anti-Mouse CD38-UNLB
SouthernBiotechMurine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral…
-
SouthernBiotech Hamster Anti-Mouse CD152-FITC
SouthernBiotechThe lymphocyte surface antigen CD152, also known as CTLA-4, is related to the costimulatory molecule CD28 and both molecules share common B7 family counter-receptors. However CD152 is thought to be a negative regulator of T cell activation and may play a role in apoptotic control of T cells. CD152…
-
SouthernBiotech Rat Anti-Mouse CD45RC-PE
SouthernBiotechCD45RC represents an exon C-dependent isoform of CD45 glycoprotein. It is expressed at high density on all B lymphocytes, at intermediate density on most CD8+ splenic T cells, and on two subpopulations of CD4+ splenic T cells with high and low density of expression. CD45RC is also present on a…
-
SouthernBiotech Rat Anti-Mouse CD25-APC
SouthernBiotechThe IL-2 receptor (IL-2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity a chain of the IL-2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O-linked carbohydrates and has a short…
-
SouthernBiotech Mouse Anti-Mouse I-Ek-FITC
SouthernBiotechThe monoclonal antibody 14-4-4S reacts with the I-Ek class II alloantigen on cells from mice of the H-2d, H-2p, and H-2r haplotypes. Cells from mice of the H-2b, H-2f, H-2q, and H-2s haplotypes do not express I-E antigen. The antibody has been reported to cross-react with the rat MHC class II…
-
SouthernBiotech Rat Anti-Mouse CD38-PACBLU
SouthernBiotechMurine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral…
-
SouthernBiotech Rat Anti-Mouse Ly-6G/Ly-6C-BIOT
SouthernBiotechLy-6G/Ly-6C, formerly known as the myeloid differentiation antigen Gr-1, is a GPI-anchored protein. In the bone marrow, the level of antigen expression is directly correlated with granulocyte differentiation and maturation. It is also transiently expressed on monocytes in the bone marrow. In the…
-
SouthernBiotech Rat Anti-Mouse CD104-LE/AF
SouthernBiotechCD45RC represents an exon C-dependent isoform of CD45 glycoprotein. It is expressed at high density on all B lymphocytes, at intermediate density on most CD8+ splenic T cells, and on two subpopulations of CD4+ splenic T cells with high and low density of expression. CD45RC is also present on a…
-
SouthernBiotech Rat Anti-Mouse CD40-UNLB
SouthernBiotechCD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first…
-
SouthernBiotech Hamster Anti-Mouse KLRG1-UNLB
SouthernBiotechThe monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their…
-
SouthernBiotech Mouse Anti-Mouse CD19-UNLB
SouthernBiotechCD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19…
-
SouthernBiotech Hamster Anti-Mouse TCRgd-LE/AF
SouthernBiotechThe TCR?d heterodimer of the CD3/T cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. It is expressed during thymopoiesis and on the small subpopulation of ?d TCR-expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial…
-
SouthernBiotech Mouse Anti-Mouse CD45.1-PE
SouthernBiotechThe CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosphorylate the Src family of protein kinases. This activity is now known to be required for signal transduction induced by T and B…
-
SouthernBiotech Mouse Anti-Mouse CD72.1-FITC
SouthernBiotechMurine CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and…
-
SouthernBiotech Rat Anti-Mouse CD24-APC
SouthernBiotechCD24, also known as heat stable antigen, is a phosphatidylinositol-linked cell surface glycoprotein that is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+CD8+CD24+ thymocytes…
-
SouthernBiotech Rat Anti-Mouse CD90.2-BIOT
SouthernBiotechCD90 (Thy-1), a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily of cell surface receptors, consists of a single V-set domain. It is expressed on thymocytes, peripheral T lymphocytes, some intraepithelial T lymphocytes, and neurons of all mouse strains. The…
-
SouthernBiotech Rat Anti-Mouse CD49e-PE
SouthernBiotechThe monoclonal antibody 5H10.27 reacts with the a5 chain (VLA-5) of the CD49e/CD29 heterodimeric fibronectin receptor. It is expressed on thymocytes, activated T cells, mast cells, and a variety of mouse cell lines. Soluble 5H10.27 antibody inhibits VLA-5-mediated functions in vitro. Immobilized…
-
SouthernBiotech Hamster Anti-Mouse CD69-BIOT
SouthernBiotechCD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. CD69 is widely expressed on…
-
SouthernBiotech Mouse Anti-Mouse Ly-49I-BIOT
SouthernBiotechThe monoclonal antibody YLI-90 reacts with the B6 allele of Ly49I, a member of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from…
-
SouthernBiotech Mouse Anti-Mouse NK1.1-FITC
SouthernBiotechNK1.1, a member of the NKR-P1 family of cell surface receptors, is a type II integral membrane glycoprotein with a C-type lectin domain. It is expressed as a disulfide-linked homodimer on all NK cells as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g.,…
-
SouthernBiotech Rat Anti-Mouse CD38-LE/AF
SouthernBiotechMurine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral…
-
SouthernBiotech Rat Anti-Mouse CD19-SPRD
SouthernBiotechCD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19…