A selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range; also inhibits autophagy by preventing vacuolar acidification necessary for autophagosome maturation.

Formula: C35H58O9 Formula weight: 622.83 CAS Number: 88899-55-2 Harmonized Tariff Code:  2941.90 Hazard Statements: H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Precautionary Statements: …

Macrolide antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Distinguishes among different types of ATPases. Inhibitor of endosomal, lysosomal and vacuolar acidification. Prevents lysosomal Ca2+ uptake. Inhibitor of autophagic degradation by rising pH and thus inactivating the lysosomal acid…