Irreversible cysteine protease inhibitor of calpain, cathepsin (B,H,L,S), papain and other cysteine proteases. Working concentration: 1-10uM.

Synonym(s): trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane Formula: C15H27N5O5 Formula weight: 357.40 CAS Number: 66701-25-5 Harmonized Tariff Code:  2925.29

A natural, potent and irreversible inhibitor of cysteine proteases; IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively; also inhibits papain, calpain, and cathepsins B and H.

E-64 L-trans-epoxysuccinyl-leucylamide-(4-guanido)-butane or N-[N-(L-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine Features CAS Number: 66701-25-5 Molecular Formula : …

E-64 is an inhibitor for thiol protease, papain, actinidin, ananain, bromelain, calpain and cathepsin B. It is an irreversible cysteine protease inhibitor that has no action on cysteine residues in other plants and does not react with low molecular weight thiols such as 2-mercaptoethanol. Specific…