ALLN is a tetrapeptide that inhibits proteases such as calpain I and II. ALLN also stimulates autophagy in vitro and suppresses I?B proteolysis. ALLN exhibits anticancer chemotherapeutic and chemopreventive potential, inducing apoptosis in colon cancer cells and inhibiting tumor formation in vivo.

Synonym(s): Ac-LLnL-CHO, ALLN Formula: C20H37N3O4 Formula weight: 383.53 Purity: 95+% CAS Number: 110044-82-1 Harmonized Tariff Code:  2924.19

Calpain inhibitor I; N-[N-(N-Acetyl-L-leucyl)-L-leucyl]-L-norleucine Specificity: Cell permeable peptide aldehyde inhibitor of calpain I and to a lesser extent calpain II. Also inhibits other neutral cysteine proteases, cathepsin B and L and the proteasome. Solubility: Soluble in DMSO or…

A synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM) cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM); prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome…