Synonyms: Aldesleukin; Lymphokine; N/A; T-cell growth factor (TCGF)
Purity: >=95% (SDS-PAGE)
Storage: -70C
UNSPSC Code: 12352200
General description: IL-2 (interleukin 2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is a type I cytokine. Recombinant human IL-2 is a 15.5kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.
Application: IL-2 (interleukin 2) human has been used for the stimulation of human primary naive T lymphocytes to study the effect of microRNA-146a on IL-2 activation-induced cell death.
Biochem/physiol Actions: IL-2/IL-2R (interleukin 2/IL-2 receptor) signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK (natural killer) cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. It is associated with recurrent oral ulcer and asthma and Mycoplasma pneumoniae infection in children. Absence of IL-2 in mice causes fatal lymphoproliferative inflammatory disease (IL-2 deficiency syndrome). IL-2 signaling involves three pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAPK (mitogen activated protein kinase), and JAK-STAT (Janus kinase - signal transducers and activators of transcription) pathways.
Physical form: Lyophilized from a PBS solution.
Reconstitution: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Preparation Note: Centrifuge the vial prior to opening.
RIDADR: NONH for all modes of transport
WGK Germany: 3