Granzyme B human, recombinant, expressed in insect cells, >=90% (SDS-PAGE)

Synonyms: Granzyme B human; Cytotoxic T-lymphocyte proteinase 2; Granzyme-2; GranzymeB; Lymphocyte protease; SECT; T-cell serine protease 1-3E

Purity: >=90% (SDS-PAGE)

Storage: -20C

UNSPSC Code: 12352200

Biochem/physiol Actions: Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells.-á After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin.-á Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases.-á This induces apoptosis in the target cell.

Physical form: Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)