Synonyms: CSF-3; Filgrastim; GM-CSF beta; MGI-1G; Pluripoietin
Purity: >=95% (SDS-PAGE)
Storage: -20C
UNSPSC Code: 12352200
General description: Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is a cytokine. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for the GCSF gene. Human and murine G-CSF is cross-species reactive. The gene encoding G-CSF is localized on human chromosome 17.
Biochem/physiol Actions: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation and function of two related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Granulocyte colony stimulating factor (G-CSF) controls the production, differentiation and function of granulocytes. It has been shown to have a role in bone repair in animal models. G-CSF has been clinically approved for neutropenia treatment.
Physical form: Lyophilized from a PBS solution.
Reconstitution: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Preparation Note: Centrifuge the vial prior to opening.
RIDADR: NONH for all modes of transport
WGK Germany: 3