Synonyms: BMP-2A; Bone morphogenetic protein 2; Bone morphogenetic protein 2A
Purity: >=95% (SDS-PAGE)
Storage: -70C
UNSPSC Code: 12352200
General description: BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-+¦ (TGF+¦) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine. BioVision's BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.
Application: BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.
Biochem/physiol Actions: BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells. In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.
Physical form: Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.
Reconstitution: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Preparation Note: Centrifuge the vial prior to opening.
RIDADR: NONH for all modes of transport
WGK Germany: 3