NUCLEODUR® is a fully synthetical type B silica (silica of 3rd generation) offering highly advanced physical properties:
- Totally spherical particle shape
- Outstanding surface microstructure
- High pressure stability
- Low metal content
NUCLEODUR® as a state-of-the-art silica is the ideal base material for modern HPLC phases. It is the result of MACHEREY-NAGEL's pioneering research in chromatography for almost 50 years.
NUCLEODUR® PFP
Pentafluorophenyl-propyl modification, multi-endcapped, USP L43
Key features:
- Hydrophobic phase with alternative selectivity in comparison to classical C18 modifications
- Separation mechanism based on 4 retention mechanisms (polar interactions (H bonds), dipole-dipole interactions, π-π interactions, hydrophobic interactions)
- Suitable for LC/MS due to low bleeding characteristics
Technical characteristics:
- Phase with pentafluorophenyl-propyl modification and multi-endcapping
- Pore size 110 Å
- Particle sizes 1.8 µm (UHPLC), 3 µm and 5 µm
- pH stability 1–9
- Carbon content 8 %
Recommended application: Aromatic and unsaturated compounds, phenols, halogenated compounds, isomers, polar compounds like pharmaceuticals, antibiotics; high retention of basic compounds