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MP Biomedicals

Glutathione, Reduced

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Glutathione is the major low molecular weight thiol compound of the living plant or animal cell. It is a tripeptide with a gamma peptide linkage between the amine group of cysteine (which is attached by normal peptide linkage to a glycine) and the carboxyl group of the glutamate side-chain. It is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides. The sulfhydryl (thiol) group (SH) of cysteine serves as a proton donor and is responsible for the biological activity of glutathione.

Glutathione suppresses human immunodeficiency virus expression in chronically infected monocytic cells. It is a useful tripeptide involved in many aspects of metabolism, including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds.

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Purity: ≥98%

Key Applications: Protein purification, Elute GST-tagged protein from glutathione agarose

Product Type: Biochemicals

Biochemical Category: Antioxidant, Cofactor, Cell Signalling Enzyme

Chemical Class: Biochemicals

Melting Point: 192-195°C (Lit.)

Optical Rotation: -16°(±) 5° (c=2, water)

Presentation: Off-white Powder

pH: Acidic (3.5% aq soln)

Solubility: Soluble in water giving clear and colorless solution (3.5% aq soln).

Storage & Handling: +4°C, store under nitrogen

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Product Detail
Thomas No.
C830X37
Mfr. No.
0210181401
CAS #
70-18-8
Description
Glutathione Reduced, 1g
Grade
>=98% Purity
Packaging Size
1 g
Packaging Type
Bottle, Glass, Amber
list price/quantitytotal
$0.00
$0.00 (0 Items)
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