CAS Number: 1397-89-3
Formula Weight: 924.08
Linear Formula: C47H73NO17
MDL No.: MFCD00877763
UNSPSC Code: 51101500
General description: Chemical structure: polyene
General description: Amphotericin B is a polyene antifungal antibiotic that is clinically used to treat systemic fungal infections.
Application: Amphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.
Biochem/physiol Actions: Amphotericin B solution has been used-. as an intraperitoneal injection for the treatment of Aspergillus fumigatus infection in mice . as a constituent of aspiration medium for the culture of Chinese Merino ewe ovaries . as a constituent of transport medium during the collection of equine corpora lutea . as a supplement in RPMI medium for the culture of the mouse-mouse B cell hybridoma 55-6 cell line
Components: This product is supplied as 250 mug/mL Amphotericin B in deionized water. It is a solution containing Amphotericin B, and the following components aimed to improve its solubility: sodium deoxycholate, sodium chloride and sodium phosphate.
Preparation Note: It is not unusual for this material to form a precipitate in aqueous solutions. Mixing the solution will redissolve most of the precipitate but, if it does not fully resolubilize, the Amphotericin B will still be suitable for use.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
RIDADR: NONH for all modes of transport