Formula: C21H39N7O12 · 1.5 H2SO4
Formula Weight: 728.69
CAS No.: 3810-74-0
Storage Temperature: 2-8°C
Application: Used to inhibit bacterial protein synthesis at the level of initiation inhibition.
Biochem/physiol Actions: Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Color: white to off-white
Form: powder
Mol Wt: calculated mol wt 1457.38 ((C21H39N7O12)2 ⋅3H2O4S)
Potency: ≥720 I.U. per mg
Storage Temp.: 2-8°C