SIGMA Streptomycin sulfate salt, powder, BioReagent, suitable for cell culture

Formula: C₂₁H₃₉N₇O₁₂ · 1.5 H₂SO₄

Formula Weight: 728.69

CAS No.: 3810-74-0

Storage Temperature: 2-8°C

Application: Recommended for use in cell culture applications at 100 mg/L. Stock solutions should be sterile-filtered and stored at 2-8 °C for up to a month or at −20 °C for extended periods. Solutions are stable at 37 °C for 3 days.

Biochem/physiol Actions: Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Protocols & Applications: Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information