Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to trigger colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. MP Premium Dextran Sulfate Sodium Salt (MW = 36,000-50,000) from MP Biomedicals is one of the most widely used products based on peer reviewed scientific publications. Over the past 15 years 3,000+ scientific publications have cited the use of our DSS.
Key features and details:
* Induces severe colitis (inflammatory bowel disease)
* Highest sulfur content: 19%
* Highest chirality: +104° of specific rotation
* Lowest pH: 6.2 at 1% solution
Molecular Weight: 36,000-50,000 Da
Application Notes: Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.
Key Applications: Acute or chronic ulcerative colitis model induction, chronic colitis associated colon cancer model induction
Grade: Colitis Grade