Zibotentan is an orally bioavailable, non-peptide ETA (endothelin) receptor-specific antagonist, with no activity against ETB receptor.
Synonyms: N-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulfonamide; ZD4054
Molecular Formula: C19H16N6O4S
Molecular Weight: 424.43
Linear Structural Formula: C19H16N6O4S
MDL Number: MFCD09955343
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC50 of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.