Voriconazole is a synthetically prepared, broad-spectrum triazole derivative of fluconazole, which shows in vitro activity against many yeasts and a broad-spectrum of mold and dermatophyte isolates. Its mode of action involves the inhibition of cytochrome P450 (CYP)-dependent enzyme, 14-a-sterol demethylase, and hence it is involved in disrupting the cell membrane and terminate the fungal growth.
Synonyms: Voriconazole; 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; UK-109496
Molecular Formula: C16H14F3N5O
Molecular Weight: 349.31
Linear Structural Formula: C16H14F3N5O
MDL Number: MFCD00905717
Application: Voriconazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.
Biochem Physiol Actions: Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.
Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.