Synonyms: 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one
Molecular Formula: C19H9Cl2F2N3OS
Molecular Weight: 436.26
Linear Structural Formula: C19H9Cl2F2N3OS
MDL Number: MFCD09834070
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKalpha. VX-745 showed 20-fold selectivity for p38alpha over p38beta and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.
Other Notes: VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.