Synonyms: 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride; TPI hydrochloride
Molecular Formula: C9H11ClN4O2 · HCl
Molecular Weight: 279.12
Linear Structural Formula: C9H11ClN4O2 · HCl
MDL Number: MFCD01571384
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.