TRKB (455-end), active, GST tagged human, PRECISIO(R) Kinase, recombinant, expressed in baculovirus infected Sf9 cells, >=70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyms: GP145-TrkB; NTRK2

Purity: >=70% (SDS-PAGE)

Activity: activity: 63-85 nmol/min·mg

Storage: -70C

UNSPSC Code: 12352200

Biochem/physiol Actions: TRKB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TRKB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and mood disorders.

Physical form: Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.