Synonyms: N-(R)-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine amide; TNF-alpha Processing Inhibitor-0; TNF-alpha Protease Inhibitor-0
Molecular Formula: C24H32N4O5
Molecular Weight: 456.53
Linear Structural Formula: C24H32N4O5
MDL Number: MFCD02684279
Purity: >=95% (HPLC)
Storage: -20C
Biochem Physiol Actions: TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE (TNF-alpha converting enzyme/ADAM17; IC50 = 100 nM). TAPI-0 also inhibits of collagenase and gelatinase. Although not specific for TACE, TAPI-0 is extensively used to block TACE-mediated TNF-alpha shedding.