Synonym(s): tert-Butyl ((oxo)dimethoxyphosphino)acetate; tert-Butyl (dimethoxyphosphinyl)acetate; Dimethyl(tert-butoxycarbonyl)methylphosphonate
Formula: (CH3O)2P(O)CH2COOC(CH3)3
Formula Weight: 224.19
CAS No.: 62327-21-3
Purity: ≥97.0% (GC)
Density: 1.131g/mLat 20°C(lit.)
Application: Reactant for:
• Preparation of phosphonate terminated PPH dendrimers as anti-HIV-1 agents
• Preparation of monodehydro diketopiperazines from ketoacyl amino acid amides via acid-catalyzed cyclization
• Preparation of α,β-unsaturated esters for use in the guanidine-catalyzed oxa-Michael addition
• Preparation of myxopyronin B and desmethyl myxopyronin B analogs, with antibacterial activity and inhibitory activity against bacterial RNA polymerase
• Allylation and subsequent ring-closing metathesis in presence of Grubbs′ catalyst or intramolecular rhodium-catalyzed cyclopropanation reactions
Other Notes: Horner-Wittig reagent giving preferentially (E)-α,β-unsat. esters which are mildly saponified with acid6,7,8. Synthesis of derivatives by reductive alkylation9
Packaging: 25, 100 mL in glass bottle
Beilstein Registry Number: 4861886
Boiling Point: 86-87°C/0.02mmHg(lit.)
Refractive Index: n20/D 1.434
Empirical Formula (Hill Notation): C5H7N3