tBuBrettPhos is a dialkylbiaryl phosphine ligand developed by the Buchwald group. It promotes cross-coupling reactions more efficiently and exhibits improved reactivity compared to other catalytic systems.
Synonyms: t-Bu Brett Phos; t-BuBrett-Phos; tertButylBrettPhos; 2-(Di-tert-butylphosphino)-2',4',6'- triisopropyl-3,6-dimethoxy-1,1'-biphenyl; t-BuBrett Phos; t-BuBrettPhos; [3,6-Dimethoxy-2',4',6'-tris(1-methylethyl) [1,1'-biphenyl]-2-yl]bis(1,1-dimethylethyl)phosphine; tert-ButylBrettPhos
Molecular Formula: C31H49O2P
Molecular Weight: 484.69
Linear Structural Formula: C31H49O2P
MDL Number: MFCD13181930
Purity: 97%
Melting Point: 166-170 C
Application: Common applications
•Buchwald-Hartwig amination and C-O coupling
•Suzuki, Negishi, Stille, Hiyama, Sonogashira cross-couplings
•α-Arylation reactionNew Applications:
•Conversion of aryl and vinyl triflates to bromides and chlorides
•Conversion of aryl triflates to aryl fluorides
•O-Arylation of ethyl acetohydroximate
•Conversion of aryl chlorides and sulfonates to nitroaromatics
Legal Information: Usage subject to US Patent 7,858,784